The win moved the Panthers to 7-11-2 overall, while Coastal dropped to 10-9-2. Birmingham-Southern will now face the winner of the last quarterfinal match of the day between third-seeded Radford and sixth-seeded High Point.
Meghan Black got the Panthers on the board first in the 58th minute with a header off a Natalie Dunham feed from about 20 yards out. Blacks goal was her first of the season.
Allie Thrasher, the reigning Big South Player of the Week, salted the game away for Birmingham-Southern when she floated a shot over the outstretched arms of CCU goalkeeper Candice Doten for the game-clinching tally. Bevin ONeill was credited with the assist on the play.
Despite the loss, Coastal controlled most of the action, outshooting Birmingham-Southern 23-8 and holding a 7-3 advantage in corner kicks. Birmingham-Southern held the edge in fouls during the course of play, 16-9. Coastals Simone Borucinski and Bobbie Parsons each posted six shots for the Lady Chants, while Thrasher had three for Birmingham-Southern.
BSCs Andria Gray, who led the Big South in saves during the regular season, had 10 saves, while Doten had just three. Doten was named the Big Souths Scholar-Athlete of the Year for the second consecutive season on Wednesday.