The Chants earn their first national seed, will receive a first-round bye and host a second-round game on Dec. 6.
Despite loss, Coastal wins a share of the Big South Championship and will make a return trip to the NCAA Division I Championship.
Joe Moglia has been named one of 20 finalists for the Eddie Robinson Award, presented to the NCAA FCS National Coach of the Year.
Coastal hosts Liberty in the teams' regluar-season finale Saturday. CCU will honor its senior prior to the game and the league's automatic bid to the playoffs will be awarded afterwards.